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https://hdl.handle.net/10356/65723
Title: | Microfluidic in vitro model to study cell mechanisms and drug efficacy | Authors: | Nishanth Venugopal Menon | Keywords: | DRNTU::Engineering::Bioengineering | Issue Date: | 2015 | Source: | Nishanth Venugopal Menon. (2015). Microfluidic in vitro model to study cell mechanisms and drug efficacy. Doctoral thesis, Nanyang Technological University, Singapore. | Abstract: | Microfluidics is a platform that is being widely used for developing in-vitro models to study various in-vivo phenomena. Our aim was to develop a simple, easy to use microfluidic device, which can be used for different cell-based applications. By performing cell patterning on-a-chip we were able to develop a microfluidic in-vitro model that could be used to perform cell-cell interaction studies and cell-substrate interaction studies. The same chip was also extended to test drugs on human cells where the efficacy of a photosensitizer to perform targeted cancer cell imaging and targeted photodynamic therapy was tested. The advantage of such a system is in the fact that they can be used to perform different types of cell studies apart from facilitating drug testing and hypothesis testing. | URI: | https://hdl.handle.net/10356/65723 | DOI: | 10.32657/10356/65723 | Schools: | School of Chemical and Biomedical Engineering | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SCBE Theses |
Files in This Item:
File | Description | Size | Format | |
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Nishanth Menon Thesis.pdf | PhD thesis of Nishanth Venugopal Menon | 4.15 MB | Adobe PDF | View/Open |
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