Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/65740
Title: Synthesis of azaheterocycles by Cu-catalyzed aerobic alkene diamination and tempo-mediated aliphatic C-H oxidation
Authors: Zhu, Xu
Keywords: DRNTU::Science::Chemistry
Issue Date: 2015
Source: Zhu, X. (2015). Synthesis of azaheterocycles by Cu-catalyzed aerobic alkene diamination and tempo-mediated aliphatic C-H oxidation. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Due to the significance of nitrogen-containing heterocycles (azaheterocycles) in biology, medicine and materials science, it is important to invent robust methodologies for synthesis of azaheterocycles using readily available nitrogen-containing starting materials in unprecedented fashions. This thesis describes methodology development for synthesis of azaheterocycles using intramolecular tactics by 1) copper-catalyzed aerobic synthesis of bi- and tricyclic amidines via intramolecular diamination of acyclic N1-pentenylamidines, and 2) TEMPO-mediated remote aliphatic C–H oxidation (oxygenation and amination) with oximes and hydrazones as the corresponding O- and N-radical precursors, respectively. This operationally simple process enables the concise assembly of substituted isoxazole, pyrazole, and hydropyridazine skeletons
URI: http://hdl.handle.net/10356/65740
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

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