dc.contributor.authorCheng, Mingen_US
dc.date.accessioned2008-09-17T11:42:08Z
dc.date.accessioned2017-07-23T08:42:08Z
dc.date.available2008-09-17T11:42:08Z
dc.date.available2017-07-23T08:42:08Z
dc.date.copyright2008en_US
dc.date.issued2008
dc.identifier.citationCheng, M. (2008). Activation states of LFA-1 (alphaL beta2) and related integrins. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/6577
dc.description.abstractLeukocyte integrins (beta2 integrins) are involved in many immune and inflammatory responses. The key function of leukocytes is impaired in the LAD-I patients due to the defects in beta2 gene. Two missense LAD-1 mutations N329S and R571C were studied. alphaLbeta2N329S can mediate constitutive adhesion to both ICAM-1 and ICAM-3, alphaIIbbeta3N339S which is corresponding to N329S in beta2 also can mediate adhesion to fibrinogen in the absence of activation reagents. Through mutagenesis analysis and conformation study, we demonstrate that this Asn is critical in shaping the I-like domain by stabilizing the conformation of the a7 helix and the ?6-a7 loop in the I-like domain.en_US
dc.rightsNanyang Technological Universityen_US
dc.subjectDRNTU::Science::Biological sciences::Molecular biologyen_US
dc.titleThe activation states of LFA-1 (alphaL beta2) and related integrinsen_US
dc.typeThesisen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.supervisorAlex Law Sai Kiten_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en_US


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