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https://hdl.handle.net/10356/6578
Title: | Chemical and enzymatic methods for selective peptide and protein modification or synthesis | Authors: | Tan, Xiaohong | Keywords: | DRNTU::Science::Biological sciences | Issue Date: | 2008 | Source: | Tan, X. H. (2008). Chemical and enzymatic methods for selective peptide and protein modification or synthesis. Doctoral thesis, Nanyang Technological University, Singapore. | Abstract: | Because almost all peptides and proteins have only one N- and one C-terminus, modification targeting terminal residues is obviously an attractive way to introduce a functional group into a peptide or a protein at a single site as compared to the reactions on the amino acid side chains. This forms the rationale of our study. First, I aim to provide reliable information about the transamination reaction to make future use of this NT-specific protein modification reaction in a much more predictable way. Second, on the peptide CT-modification aspect, this study aims to develop new chemical and enzymatic methods to synthesize peptidyl thioesters and thioacids which are important derivatives to introduce new functional groups onto the C-termini of proteins and peptides. | URI: | https://hdl.handle.net/10356/6578 | DOI: | 10.32657/10356/6578 | Schools: | School of Biological Sciences | Rights: | Nanyang Technological University | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Theses |
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SBS-THESES_24.pdf | 2.61 MB | Adobe PDF | View/Open |
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