Please use this identifier to cite or link to this item:
Title: Chemical and enzymatic methods for selective peptide and protein modification or synthesis
Authors: Tan, Xiaohong
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2008
Source: Tan, X. H. (2008). Chemical and enzymatic methods for selective peptide and protein modification or synthesis. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Because almost all peptides and proteins have only one N- and one C-terminus, modification targeting terminal residues is obviously an attractive way to introduce a functional group into a peptide or a protein at a single site as compared to the reactions on the amino acid side chains. This forms the rationale of our study. First, I aim to provide reliable information about the transamination reaction to make future use of this NT-specific protein modification reaction in a much more predictable way. Second, on the peptide CT-modification aspect, this study aims to develop new chemical and enzymatic methods to synthesize peptidyl thioesters and thioacids which are important derivatives to introduce new functional groups onto the C-termini of proteins and peptides.
DOI: 10.32657/10356/6578
Rights: Nanyang Technological University
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

Files in This Item:
File Description SizeFormat 
SBS-THESES_24.pdf2.61 MBAdobe PDFThumbnail

Page view(s) 50

Updated on May 8, 2021

Download(s) 20

Updated on May 8, 2021

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.