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|Title:||Chemical and enzymatic methods for selective peptide and protein modification or synthesis.||Authors:||Tan, Xiaohong.||Keywords:||DRNTU::Science::Biological sciences||Issue Date:||2008||Source:||Tan, X. H. (2008). Chemical and enzymatic methods for selective peptide and protein modification or synthesis. Doctoral thesis, Nanyang Technological University, Singapore.||Abstract:||Because almost all peptides and proteins have only one N- and one C-terminus, modification targeting terminal residues is obviously an attractive way to introduce a functional group into a peptide or a protein at a single site as compared to the reactions on the amino acid side chains. This forms the rationale of our study. First, I aim to provide reliable information about the transamination reaction to make future use of this NT-specific protein modification reaction in a much more predictable way. Second, on the peptide CT-modification aspect, this study aims to develop new chemical and enzymatic methods to synthesize peptidyl thioesters and thioacids which are important derivatives to introduce new functional groups onto the C-termini of proteins and peptides.||URI:||http://hdl.handle.net/10356/6578||Rights:||Nanyang Technological University||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SBS Theses|
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