Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/6578
Title: Chemical and enzymatic methods for selective peptide and protein modification or synthesis.
Authors: Tan, Xiaohong.
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2008
Source: Tan, X. H. (2008). Chemical and enzymatic methods for selective peptide and protein modification or synthesis. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Because almost all peptides and proteins have only one N- and one C-terminus, modification targeting terminal residues is obviously an attractive way to introduce a functional group into a peptide or a protein at a single site as compared to the reactions on the amino acid side chains. This forms the rationale of our study. First, I aim to provide reliable information about the transamination reaction to make future use of this NT-specific protein modification reaction in a much more predictable way. Second, on the peptide CT-modification aspect, this study aims to develop new chemical and enzymatic methods to synthesize peptidyl thioesters and thioacids which are important derivatives to introduce new functional groups onto the C-termini of proteins and peptides.
URI: http://hdl.handle.net/10356/6578
Rights: Nanyang Technological University
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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