dc.contributor.authorTan, Xiaohongen_US
dc.date.accessioned2008-09-17T11:42:09Z
dc.date.accessioned2017-07-23T08:42:08Z
dc.date.available2008-09-17T11:42:09Z
dc.date.available2017-07-23T08:42:08Z
dc.date.copyright2008en_US
dc.date.issued2008
dc.identifier.citationTan, X. H. (2008). Chemical and enzymatic methods for selective peptide and protein modification or synthesis. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/6578
dc.description.abstractBecause almost all peptides and proteins have only one N- and one C-terminus, modification targeting terminal residues is obviously an attractive way to introduce a functional group into a peptide or a protein at a single site as compared to the reactions on the amino acid side chains. This forms the rationale of our study. First, I aim to provide reliable information about the transamination reaction to make future use of this NT-specific protein modification reaction in a much more predictable way. Second, on the peptide CT-modification aspect, this study aims to develop new chemical and enzymatic methods to synthesize peptidyl thioesters and thioacids which are important derivatives to introduce new functional groups onto the C-termini of proteins and peptides.en_US
dc.rightsNanyang Technological Universityen_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleChemical and enzymatic methods for selective peptide and protein modification or synthesisen_US
dc.typeThesisen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.supervisorLiu Chuan Faen_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SBS)en_US


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