Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/65977
Title: Study on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast cancer
Authors: Fu, Afu
Keywords: DRNTU::Engineering::Bioengineering
Issue Date: 2016
Source: Fu, A. (2016). Study on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast cancer. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Breast cancer remains curable until the metastatic cancer cells disseminate beyond the regional lymph nodes. The 5-year relative survival rate of stage IV breast cancer is less than 22%. Therefore, strategies to prevent the dissemination of breast cancer cells into bloodstream, eliminate the circulating tumor cells (CTCs), or suppress the proliferation of disseminated tumor cells (DTCs), can potentially inhibit cancer progression and improve the survival of breast cancer patients. So far, the mechanisms of how hemodynamic shear force induces apoptosis of CTCs and how metastatic breast cancer cell manage to survive in blood circulation are still unclear. Therefore, this thesis focused on the survival mechanisms of CTCs and aims to identify functional biomarkers and develop therapeutic strategies for metastatic breast cancer.
URI: https://hdl.handle.net/10356/65977
DOI: 10.32657/10356/65977
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Theses

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