dc.contributor.authorFu, Afu
dc.date.accessioned2016-02-11T08:23:32Z
dc.date.accessioned2017-07-23T08:26:24Z
dc.date.available2016-02-11T08:23:32Z
dc.date.available2017-07-23T08:26:24Z
dc.date.issued2016
dc.identifier.citationFu, A. (2016). Study on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast cancer. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/65977
dc.description.abstractBreast cancer remains curable until the metastatic cancer cells disseminate beyond the regional lymph nodes. The 5-year relative survival rate of stage IV breast cancer is less than 22%. Therefore, strategies to prevent the dissemination of breast cancer cells into bloodstream, eliminate the circulating tumor cells (CTCs), or suppress the proliferation of disseminated tumor cells (DTCs), can potentially inhibit cancer progression and improve the survival of breast cancer patients. So far, the mechanisms of how hemodynamic shear force induces apoptosis of CTCs and how metastatic breast cancer cell manage to survive in blood circulation are still unclear. Therefore, this thesis focused on the survival mechanisms of CTCs and aims to identify functional biomarkers and develop therapeutic strategies for metastatic breast cancer.en_US
dc.format.extent251 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Engineering::Bioengineeringen_US
dc.titleStudy on survival mechanisms of circulating tumor cells and identification of metastatic biomarkers for breast canceren_US
dc.typeThesis
dc.contributor.supervisor2Qian Luo, Kathyen_US
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.degreeDOCTOR OF PHILOSOPHY (SCBE)en_US
dc.identifier.doihttps://doi.org/10.32657/10356/65977


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