Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/66312
Title: Developing micro and nanostrategies for human cancer detection and therapy
Authors: Tng, Danny Jian Hang
Keywords: DRNTU::Engineering
Issue Date: 2016
Source: Tng, D. J. H. (2016). Developing micro and nanostrategies for human cancer detection and therapy. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: In this thesis, micro and nano technologies were employed to create cancer therapies that can be customized for individuals by enhancing the therapeutic effects while simultaneously reducing the possible side-effects. Using a newly engineered Lab-On-a-Chip drug testing device, optimized drug formulations for killing the cancer in vitro were determined. These drug formulations were then loaded into multifunctional hybrid-polymeric nanoparticles for enhancing tumor uptake and improving providing targeted delivery in vivo. In addition, these nanoparticles were equipped with multimodal imaging capabilities (e.g. fluorescence and magnetic resonance imaging), allowing real-time monitoring of the biodistribution and efficacy of the nanodrugs in vivo. Lastly, to further improve the delivery of the nanodrugs locally, biocompatible microelectromechanical system devices were fabricated and implanted into small animals for evaluation of the pharmacokinetics of programmed drug delivery. The use of these approaches allows treatment to be tailored for the individual, thereby enhancing the therapeutic outcomes.
URI: http://hdl.handle.net/10356/66312
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:EEE Theses

Files in This Item:
File Description SizeFormat 
DR NTU.pdf
  Restricted Access
Main Article5.75 MBAdobe PDFView/Open

Page view(s)

184
Updated on Jun 24, 2021

Download(s) 50

37
Updated on Jun 24, 2021

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.