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Title: The role of transportin-1 in the ciliary targeting of membrane proteins
Authors: Madugula, Viswanadh
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2016
Source: Madugula, V. (2016). The role of transportin-1 in the ciliary targeting of membrane proteins. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: The sensory functions of cilia are dependent on the enrichment of ciliary resident proteins. While it is known that ciliary targeting signals (CTSs) specifically target ciliary proteins to cilia, it is less clear how CTSs facilitate the entry and retention of ciliary residents at molecular level. We found that non-ciliary membrane reporters could passively diffuse to cilia via the lateral transport pathway and the translocation of membrane reporters through ciliary diffusion barrier could be facilitated by importin binding motifs/domains. We further discovered that a novel ternary complex, comprising Rab8, TNPO1 and CTS, could be assembled or disassembled under the guanine nucleotide exchange of Rab8. Our study suggests a novel mechanism in which Rab8/TNPO1/CTS complex mediates selective entry and retention of cargos within cilia.
DOI: 10.32657/10356/67319
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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