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|Title:||Synthesis of high value chemicals from biomass platform chemicals||Authors:||Koh, Jackson Peng Fei||Keywords:||DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis||Issue Date:||2016||Source:||Koh, J. P. F. (2016). Synthesis of high value chemicals from biomass platform chemicals. Doctoral thesis, Nanyang Technological University, Singapore.||Abstract:||In this thesis, the conversion of biomass to several high value chemicals via versatile and synthetically useful platform chemicals was described. These high value chemicals include a common intermediate that allow access to several potent NK1 receptor antagonists which are associated with the treatment of anxiety and emesis, as well as biologically active natural products aspergillides A and B with cytotoxic activity against mouse lymphocytic leukemia cell (L1210). In particular, the syntheses of aspergillides A and B was achieved such that all of the carbons present are derived from biomass derived platform chemicals. These demonstrate the feasibility of constructing valuable biologically active compounds using a sustainable chemical feedstock like biomass.||URI:||https://hdl.handle.net/10356/67322||DOI:||10.32657/10356/67322||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SPMS Theses|
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|Koh Peng Fei Jackson G1300873L Thesis - Revised.pdf||Final Thesis||8.76 MB||Adobe PDF|
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