Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/67357
Title: Investigating the anti-cancer potential of phytochemicals
Authors: Nawshein Shikkander
Keywords: DRNTU::Science
Issue Date: 2016
Abstract: Breast cancer is one of the most prevalent forms of cancer among women across the world. The rapid disease progression has identified various subtypes, each having independent prognostic and therapeutic associations. The rising cost and the detrimental side effects of current day treatment have encouraged scientists to explore alternative therapeutic options for breast cancer. Plant derived phytochemicals have been a primary research target for decades. Its safe nature and relative abundance have been a driving factor in breast cancer therapeutics. The objective of this project was to investigate the anti-cancer potential of two soy derived phytochemicals; Daidzein and Genistein on subtype variant MDA-MB-231 and MCF-7 breast cancer cells. Results from MTT assay showed that proliferation of MDA-MB-231 cells (ER-, PR- and HER2+) was inhibited by both the phytochemicals at both high and low drug concentrations. However, the phytochemicals displayed a biphasic response on the proliferation of MCF-7 (ER+, PR+ and HER2 -) cells. Results from transwell migration assay showed that migration of MDA-MB-231 cells was better inhibited by phytochemicals as opposed to MCF-7 cells. These results proved that phytochemicals exhibited subtype-dependent anti-cancer effects on varying breast cancer cells. Future studies include the validation of the results obtained, through characterization studies.
URI: http://hdl.handle.net/10356/67357
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)

Files in This Item:
File Description SizeFormat 
FYP (1).pdf
  Restricted Access
82.9 kBAdobe PDFView/Open

Page view(s)

127
Updated on Jun 21, 2021

Download(s) 50

20
Updated on Jun 21, 2021

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.