Please use this identifier to cite or link to this item:
Title: The role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in colorectal cancer cells
Authors: Chew, Clement Kai Hong
Keywords: DRNTU::Science
Issue Date: 2016
Abstract: In colorectal cancer (CRC), plasma levels of LRG1 is observed to be increased in female patients before their diagnosis of CRC. In addition, LRG1 is reported to positively correlate colonic adenoma in a rodent model of CRC. More recently, LRG1 was reported to be able to modulate epithelial-mesenchymal transition of some CRC cell lines. Attempts to elucidate how LRG1 modulates TGF-β signalling, proliferation rate and cell cycle in HCT-15 and HT-29 CRC cell lines were made via western blot, LRG1 overexpression and MTS proliferation assays. Preliminary data hints that LRG1 upregulates TGF-β signaling molecules promote proliferation of HCT-15 and HT-29 CRC cells lines. This presents LRG1 a potential cancer drug target in the context of CRC.
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)

Files in This Item:
File Description SizeFormat 
The Role of LRG1 in CRC.pdf
  Restricted Access
1.36 MBAdobe PDFView/Open

Page view(s) 50

Updated on Nov 25, 2020

Download(s) 50

Updated on Nov 25, 2020

Google ScholarTM


Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.