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https://hdl.handle.net/10356/68347
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DC Field | Value | Language |
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dc.contributor.author | Lee, Angeline Jia Hui | - |
dc.date.accessioned | 2016-05-25T07:07:37Z | - |
dc.date.available | 2016-05-25T07:07:37Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | http://hdl.handle.net/10356/68347 | - |
dc.description.abstract | Graphene quantum dot (GQD) is a nanoscale fluorescent particle which has various applications. It is synthesized from a suitable carbon precursor by either a top- down or a bottom- up approach like microwave- assisted, solvothermal, cage opening and other exfoliation reactions. For this project, GQDs were used and studied for as a drug carrier. The target cells are HeLa, which are cervical cancer cells. The optimal condition for the drug loading onto the GQDs occurred at pH 8 while drug release was triggered rapidly at pH 5.5 (tumor pH). This experimental result provides an indication that the loading and release of beta- Lapachone can be controlled by changes in the pH of the solution. This characteristic proves to be a great advantage as tumor cells are slightly acidic in nature. The biocompatibility assay ensured the non-cell toxic nature of GQDs. Based on the cell viability (MTT) test, the results showed that in the presence of free drug and beta- lapachone- loaded GQD there was a significant reduction in cancer cell viability. This study would thus prove the efficacy of GQDs as drug carriers to cancerous cells. | en_US |
dc.format.extent | 42 p. | en_US |
dc.language.iso | en | en_US |
dc.rights | Nanyang Technological University | - |
dc.subject | DRNTU::Engineering | en_US |
dc.title | Graphene quantum dot as drug carriers | en_US |
dc.type | Final Year Project (FYP) | en_US |
dc.contributor.supervisor | Chen Peng | en_US |
dc.contributor.school | School of Chemical and Biomedical Engineering | en_US |
dc.description.degree | Bachelor of Engineering (Chemical and Biomolecular Engineering) | en_US |
item.fulltext | With Fulltext | - |
item.grantfulltext | restricted | - |
Appears in Collections: | SCBE Student Reports (FYP/IA/PA/PI) |
Files in This Item:
File | Description | Size | Format | |
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FYP report_Angeline Lee_Final.pdf Restricted Access | 2 MB | Adobe PDF | View/Open |
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