Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/68847
Title: Palladacycle catalyzed asymmetric hydrophosphination : pushing the boundaries in C*-P bond formation
Authors: Chew, Jonathan Renta
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
Issue Date: 2016
Source: Chew, J. R. (2016). Palladacycle catalyzed asymmetric hydrophosphination : pushing the boundaries in C*-P bond formation. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: The significance of chiral phosphines is well-known in the field of Chemistry; yet conventional approaches for their preparation are wasteful, expensive and cumbersome. This thesis reports on the direct preparation of chiral phosphines using a palladacycle catalyst via the addition of secondary phosphines to novel and challenging prochiral substrates, thereby generating a library of highly enantioenriched functionalised phosphines in typically high yields. Throughout the studies, novel compounds which have never been known to be Michael acceptors have been uncovered, as well as the never before observed enantiodivergence in P-H addition systems. The undertaken studies and the results obtained further our collective understanding of various reaction mechanisms and methodologies, representing a salient contribution to Chemistry in general.
URI: https://hdl.handle.net/10356/68847
DOI: 10.32657/10356/68847
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

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