Selective tropical fruit waste component exhibiting adipocyte differentiation inhibition, a future anti-obesity therapeutic strategy
Asyifah Mohamed Rashid
Date of Issue2016-12-29
School of Physical and Mathematical Sciences
The prevalence of obesity globally today has become significantly prominent and this has posed serious challenges and problems for professionals in the health sector to combat. The rising side effects of existing synthetic drugs used to medically treat obesity have also been concerning and the need for alternative measures of treatment is greatly in demand. In this thesis, a range of studies being done to investigate the potential of natural components, particularly, fruit waste components, as an alternative source for obesity treatment will be discussed. The elucidation of bioactive compounds present in the respective active fruit waste components will be identified and its biomechanism were investigated. In addition, comparative study to investigate the difference in effectiveness between the waste component and flesh of a fruit as well ripening stages of a fruit were also investigated in two separate chapters of this thesis. Finally, for a holistic investigation of experimental extraction condition, an optimization study to explore the most optimal condition to yield the highest amount of bioactive compound(s) from a fruit component was also determined.