Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/69628
Title: Investigating the signaling properties of myeloid specific integrin αMβ2 (CD11BCD18)
Authors: Ong, Li Teng
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2017
Source: Ong, L. T. (2017). Investigating the signaling properties of myeloid specific integrin αMβ2 (CD11BCD18). Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: The cell adhesion molecules integrins are important in immune homeostasis. Dysfunctional or deregulated integrins can lead to a compromised immune system or generate overt inflammatory responses. Apart from its well-established role as a phagocytic receptor, the myeloid specific integrin αMβ2 (CD11bCD18) is involved in cell migration, leukocyte survival and immune tolerance. We are therefore interested to study the signaling conduits of integrin αMβ2 and determine the roles of the integrin αMβ2 cytoplasmic tails in these events. Herein, we showed for the first time a Systemic Lupus Erythematosus associated single nucleotide polymorphism on integrin αMβ2, SNP rs1143678, exhibits pro-inflammatory properties and it generates a non-canonical docking site in integrin αM cytoplasmic tail for 14-3-3ζ. We also identified RGS10 as a possible integrin αMβ2 downstream signaling target. Finally, we generated kindlin-3 knockdown macrophages to study its regulation of integrin αMβ2 signaling in inflammation.
URI: http://hdl.handle.net/10356/69628
DOI: 10.32657/10356/69628
Schools: School of Biological Sciences 
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

Files in This Item:
File Description SizeFormat 
Revised Final 20170119 3.7cm margin.pdf5.17 MBAdobe PDFThumbnail
View/Open

Page view(s) 50

466
Updated on Jun 18, 2024

Download(s) 50

150
Updated on Jun 18, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.