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dc.contributor.authorOng, Li Teng
dc.identifier.citationOng, L. T. (2017). Investigating the signaling properties of myeloid specific integrin αMβ2 (CD11BCD18). Doctoral thesis, Nanyang Technological University, Singapore.
dc.description.abstractThe cell adhesion molecules integrins are important in immune homeostasis. Dysfunctional or deregulated integrins can lead to a compromised immune system or generate overt inflammatory responses. Apart from its well-established role as a phagocytic receptor, the myeloid specific integrin αMβ2 (CD11bCD18) is involved in cell migration, leukocyte survival and immune tolerance. We are therefore interested to study the signaling conduits of integrin αMβ2 and determine the roles of the integrin αMβ2 cytoplasmic tails in these events. Herein, we showed for the first time a Systemic Lupus Erythematosus associated single nucleotide polymorphism on integrin αMβ2, SNP rs1143678, exhibits pro-inflammatory properties and it generates a non-canonical docking site in integrin αM cytoplasmic tail for 14-3-3ζ. We also identified RGS10 as a possible integrin αMβ2 downstream signaling target. Finally, we generated kindlin-3 knockdown macrophages to study its regulation of integrin αMβ2 signaling in inflammation.en_US
dc.format.extent163 p.en_US
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleInvestigating the signaling properties of myeloid specific integrin αMβ2 (CD11BCD18)en_US
dc.contributor.supervisorTan Suet Mienen_US
dc.contributor.schoolSchool of Biological Sciencesen_US​Doctor of Philosophy (SBS)en_US
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