Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRocamora, Frances Maureen C.
dc.identifier.citationRocamora, F. M. C. (2017). Characterization of artemisinin resistance in plasmodium falciparum. Doctoral thesis, Nanyang Technological University, Singapore.
dc.description.abstractArtemisinins are an important class of antimalarials because of their remarkable antimalarial activity and exceptional safety profile. However, the decline in efficacy of artemisinin-based drugs jeopardizes global efforts that aim to control and ultimately eradicate malaria. In order to better understand the Artemisinin resistance phenotype, we developed Artemisinin-resistant parasite lines derived from two isogenic clones (6A and 11C) of the 3D7 strain of Plasmodium falciparum using a selection regimen that mimics how parasites interact with the drug in infected patients. Long term in vitro selection produced two parasite lines that displayed profound stage-specific resistance to artemisinin and its relative compounds. Chemosensitivity and transcriptional profiling of ART-resistant parasites indicate that enhanced adaptive responses against oxidative stress and protein damage are associated with the artemisinin resistance phenotype. Genomic characterization of both parasite lines also identified a spectrum of mutated and copy number-variable genes that could play a role in mediating artemisinin sensitivity. Collectively, this work represents a useful resource for investigating artemisinin response and resistance in P. falciparum.en_US
dc.format.extent208 p.en_US
dc.subjectDRNTU::Science::Biological sciences::Molecular biologyen_US
dc.titleCharacterization of artemisinin resistance in plasmodium falciparumen_US
dc.contributor.supervisorZbynek Bozdechen_US
dc.contributor.schoolSchool of Biological Sciencesen_US​Doctor of Philosophy (SBS)en_US
item.fulltextWith Fulltext-
Appears in Collections:SBS Theses
Files in This Item:
File Description SizeFormat 
RocamoraF_SBS_PhD Thesis.pdfSBS PhD Thesis7.63 MBAdobe PDFThumbnail

Google ScholarTM


Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.