Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/72647
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dc.contributor.authorRocamora, Frances Maureen C.
dc.date.accessioned2017-09-04T08:24:21Z
dc.date.available2017-09-04T08:24:21Z
dc.date.issued2017
dc.identifier.citationRocamora, F. M. C. (2017). Characterization of artemisinin resistance in plasmodium falciparum. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/72647
dc.description.abstractArtemisinins are an important class of antimalarials because of their remarkable antimalarial activity and exceptional safety profile. However, the decline in efficacy of artemisinin-based drugs jeopardizes global efforts that aim to control and ultimately eradicate malaria. In order to better understand the Artemisinin resistance phenotype, we developed Artemisinin-resistant parasite lines derived from two isogenic clones (6A and 11C) of the 3D7 strain of Plasmodium falciparum using a selection regimen that mimics how parasites interact with the drug in infected patients. Long term in vitro selection produced two parasite lines that displayed profound stage-specific resistance to artemisinin and its relative compounds. Chemosensitivity and transcriptional profiling of ART-resistant parasites indicate that enhanced adaptive responses against oxidative stress and protein damage are associated with the artemisinin resistance phenotype. Genomic characterization of both parasite lines also identified a spectrum of mutated and copy number-variable genes that could play a role in mediating artemisinin sensitivity. Collectively, this work represents a useful resource for investigating artemisinin response and resistance in P. falciparum.en_US
dc.format.extent208 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Science::Biological sciences::Molecular biologyen_US
dc.titleCharacterization of artemisinin resistance in plasmodium falciparumen_US
dc.typeThesis
dc.contributor.supervisorZbynek Bozdechen_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.degree​Doctor of Philosophy (SBS)en_US
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