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Title: Development of phosphapalladacycles as potential catalysts for asymmetric synthesis
Authors: Chiew, Jun Xuan
Keywords: DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds
DRNTU::Science::Chemistry::Inorganic chemistry::Metals
Issue Date: 2017
Source: Chiew, J. X. (2017). Development of phosphapalladacycles as potential catalysts for asymmetric synthesis. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: A series of chiral tertiary phosphine ligands have been prepared via two synthetic approaches, namely through the optical resolution of racemic phosphines, and the asymmetric hydrophosphination reaction of enones with secondary phosphines promoted by chiral palladacycles. The ortho-palladation of the chiral phosphine ligands resulted in the formation of optically active CP-palladacycles containing a five-membered ring structure. The properties of the newly synthesized phosphapalladacycles were studied by NMR spectroscopy and single crystal X-ray crystallography. The potential use of the phosphapalladacycles as catalysts was explored in the enantioselective addition of various diarylphosphines to benzoquinone for generating P-stereogenic diarylphosphinites readily convertible into various phosphines and their derivatives.
DOI: 10.32657/10356/72660
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Theses

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