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Title: Structural plasticity of BCL-2 family proteins and its functional implication in apoptosis
Authors: Choi, Minjoo
Keywords: DRNTU::Science::Biological sciences::Molecular biology
Issue Date: 2018
Source: Choi, M. (2018). Structural plasticity of BCL-2 family proteins and its functional implication in apoptosis. Doctoral thesis, Nanyang Technological University, Singapore.
Abstract: Dysregulated apoptosis has been implicated in the development of several diseases including cancer and neurodegenerative diseases. Bcl-2 family proteins regulate mitochondrial apoptosis through homo- and hetero-dimerization between pro- and anti-apoptotic Bcl-2 proteins. The first part of this study has been devoted to address the structural transition of Bcl-xL in forming domain-swapped dimer in the presence of n-octyl-β-D-Maltoside detergent. We postulated that this structural plasticity of Bcl-xL might play a regulatory role in the modulation of mitochondrial calcium homeostasis. In the second part of this study, we focused on the molecular interaction between Bcl-xL and Voltage-Dependent Anion Channel (VDAC). While VDAC has been reported to interact with Bcl-xL to regulate mitochondrial calcium homeostasis, detailed molecular basis of the interaction between the two molecules remains elusive. Hence, we aim to provide structural insights into the interaction of Bcl-xL with VDAC N-terminal peptides using NMR spectroscopy.
DOI: 10.32657/10356/73522
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Theses

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