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|Title:||Using colloidal disassembly to determine molecular stability of DNA-coated magnetic micro-particles||Authors:||Tan, Keith Wei Rong||Keywords:||DRNTU::Science::Biological sciences::Biophysics||Issue Date:||2018||Abstract:||Recently, methods to control the strength of the inter-bead interaction when using DNA G-quadruplexes to link magnetic micro-beads were explored and established. Using those techniques, we propose a method to assess the e ectiveness of G-quadruplex ligands by studying it's e ect on the colloidal interactions of G-quadruplex DNA-coated magnetic micro-particle chains. By adjusting the concentration of K+ ions in the bu er solution, we select a suitable concentration of the K+ whereby, the natural dissociation of the magnetic micro-particle chains is optimal.||URI:||http://hdl.handle.net/10356/74927||Fulltext Permission:||embargo_restricted_20230531||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SPMS Student Reports (FYP/IA/PA/PI)|
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