Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/75248
Title: Methods to improve bioavailability of peptide drug delivery
Authors: See, Hock Ming
Keywords: DRNTU::Engineering::Bioengineering
Issue Date: 2018
Abstract: Peptide and protein therapeutics in the biomedical application has been widely researched in the past decades, however, their usage is hampered by various systemic barriers which greatly reduce the bioavailability and drug efficacy. Oral delivery is most preferred due to its great patient compliance and noninvasiveness, though the occurrence of proteolytic degradation and the presence of gastrointestinal barriers lower the drug stability and absorption effectiveness of protein/peptide drugs. Direct structural modifications, carrier systems, absorption enhancers and enzyme inhibitors are being studied to overcome the stability and absorption issues. Among these delivery strategies, carrier systems provide lots of flexible possibilities and favorable advantages to facilitate oral delivery, while liposomes being the most potential candidate to address these oral delivery issues. For possible future developments to improve the liposomal carrier systems, vitamin B12 grafted liposomes and the coadministration of archaeal lipids modified liposomes with bile salts as absorption enhancers are also discussed.
URI: http://hdl.handle.net/10356/75248
Schools: School of Chemical and Biomedical Engineering 
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Student Reports (FYP/IA/PA/PI)

Files in This Item:
File Description SizeFormat 
AY17-18 FYP report-SEE HOCK MING-U1420021G.pdf
  Restricted Access
1.15 MBAdobe PDFView/Open

Page view(s)

369
Updated on Jul 19, 2024

Download(s) 50

54
Updated on Jul 19, 2024

Google ScholarTM

Check

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.