Optimization of drug release profile for 2D and 3D electrospun fibres for liver fibrosis

Abstract

The increasing trend of liver-related diseases has resulted in numerous cases of death and is currently highly ranked in terms of deadly diseases. Therefore, more focus has been put on finding a solution for the various type of liver diseases. All liver diseases progress through liver fibrosis defined by scar tissue formation. With the fast development of health-related researches, many methods have been proposed to overcome the symptoms of liver fibrosis. However, there are many limitations to the present methods. One of the methods that had recently come into the spotlight is the use of electrospinning to fabricate fibre to prepare scaffolds for drug delivery. Our current work investigates the effects of electrospinning on the fabricated fibre and the process of encapsulating Decorin in the electrospun fibre for release study and full encapsulation study. There is also the use of BSA as the protein to optimise the encapsulation percentage within the electrospun fibre. Characterization method like Micro BCA Assay, ELISA Assay, spectrophotometry and scanning electron microscopy (SEM) will be employed.