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dc.contributor.authorLim, Venus Wen Xuan
dc.description.abstractThe research of our laboratory appears to be promising in demonstrating the outcome of an extended lifespan when aged C. elegans are fed a high glucose diet. On the other hand, young C. elegans are known have a reduced lifespan when fed a high glucose diet. Building upon the study of aged C. elegans, we aimed to analyse the effects of osmotic stress-induced by a high glucose diet in aged C. elegans. Our results demonstrate that extension of lifespan is an outcome of high glucose diet-induced osmotic stress. Intracellular glucose content and glucose metabolism were similarly maintained in aged worms fed a normal diet and a high glucose diet. This indicates that the aged worms do not metabolise sugar and hence lifespan extension can be contributed to other factors and not glucose metabolism. Lifespan of aged C. elegans were extended when fed a high glucose diet of D-glucose, L-glucose and D-sorbitol. Albeit, much remains to be answered, the relationship between osmotic stress-induced by high glucose diet and aging would serve to unravel the interconnected pathways that underlie these diseases.en_US
dc.format.extent35 p.en_US
dc.rightsNanyang Technological University
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.titleCharacterising the anti-aging role of high glucose diet-induced osmotic stress in aged Caenorhabditis elegansen_US
dc.typeFinal Year Project (FYP)en_US
dc.contributor.supervisorGuillaume Thibaulten_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.description.degreeBachelor of Science in Biological Sciencesen_US
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Appears in Collections:SBS Student Reports (FYP/IA/PA/PI)

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