Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/77727
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dc.contributor.authorChiang, Grace Li Ying
dc.date.accessioned2019-06-04T07:33:09Z
dc.date.available2019-06-04T07:33:09Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/10356/77727
dc.description.abstractIn the early centuries, daily necessities (vinegar, honey, grease and oil) are incorporated into wound dressing in order to maintain and control infection of the wound site. However, these wound dressings are not efficient for the treatment of chronic non-healing wounds. Over many centuries, the modern wound care management has incorporated tissue engineering to fabricate smart wound dressing materials that can deposit collagen to accelerate the wound healing rate and mimic the structural environment of host tissue without causing adverse host response from occurring. With the complex structure of ECM proteins found in the natural waste material that is discarded as surgical waste, human adipose tissue-derived extracellular matrix (Ad-ECM) can be potentially used as the source of ECM. After extracting Ad-ECM, the naturally derived material was assessed to determine whether it is safe to be used by evaluating the lipid and DNA content of the extracted product. From the experimental data, the DNA concentration of the extracted Ad-ECM was less than 50ng/mg with insignificant presence of lipid molecules which proved successful decellularization and delipidation. Decellularized Ad-ECM has considerably poor mechanical properties and low biostability. Hence, homogenization with 1,4-Butanediol diglycidyl ether ≥95% (BDE) crosslinker was carried out to improve the mechanical and thermal properties of the scaffold. It was found that with increasing concentrations of BDE-crosslinker (1w/w%, 2.5w/w% and 5w/w%), the mechanical properties and thermal stability improved with an increasing trend in both the modulus and denaturation temperature. However, the modulus of 5w/w% BDE Ad-ECM was found to be significantly lower than the modulus of native skin tissue. This will not allow the scaffold to withstand the load that is applied to the native skin tissue and it can be prone to damage during handling. Nonetheless, Ad-ECM and BDE-crosslinked Ad-ECM have a porous structure which provides a good housing environment for cells as it can enable the transportation of nutrients to cells and removal of metabolic waste. Therefore, the BDE-crosslinked Ad-ECM have to be further optimized to improve the mechanical properties of this scaffolding material.en_US
dc.format.extent49 p.en_US
dc.language.isoenen_US
dc.rightsNanyang Technological University
dc.subjectDRNTU::Engineering::Materialsen_US
dc.titleDevelopment of smart dressing materials for wound healingen_US
dc.typeFinal Year Project (FYP)en_US
dc.contributor.supervisorDalton Tay Chor Yongen_US
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.description.degreeBachelor of Engineering (Materials Engineering)en_US
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Appears in Collections:MSE Student Reports (FYP/IA/PA/PI)
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