Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/78035
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dc.contributor.authorAli, Ashik
dc.date.accessioned2019-06-11T05:33:45Z
dc.date.available2019-06-11T05:33:45Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/10356/78035
dc.description.abstractThis paper analyzes the effects of MiRNA 150 and 885 on liver fibrosis. To establish if these MiRNAs are pro-fibrotic or anti-fibrotic, fibrotic expression of HSC Activation and Quiescence Markers are quantified after over-expressing the MiRNAs in LX2 cells. Our results suggest that MiRNA 150 is pro-fibrotic due to the relative over-expression of classical HSC activation markers while MiRNA 885 tends to be inconclusive with inconsistent results. This paper also serves as a guide for cloning and testing MiRNAs in cells for any gene expression in-vitro. MiRNA 150 can be further studied on a protein level for potential therapeutic value to those suffering from Liver fibrosis.en_US
dc.format.extent46 p.en_US
dc.language.isoenen_US
dc.rightsNanyang Technological University
dc.subjectDRNTU::Science::Biological sciencesen_US
dc.subjectDRNTU::Engineering::Bioengineeringen_US
dc.titleEffect of micro-RNA 150 and 885 on liver fibrosisen_US
dc.typeFinal Year Project (FYP)en_US
dc.contributor.supervisorDang Thuy Tramen_US
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.degreeBachelor of Engineering (Bioengineering)en_US
dc.contributor.organizationA*STARen_US
dc.contributor.supervisor2Raymond Ngen_US
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Appears in Collections:SCBE Student Reports (FYP/IA/PA/PI)
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