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Title: Effect of micro-RNA 150 and 885 on liver fibrosis
Authors: Ali, Ashik
Keywords: DRNTU::Science::Biological sciences
Issue Date: 2019
Abstract: This paper analyzes the effects of MiRNA 150 and 885 on liver fibrosis. To establish if these MiRNAs are pro-fibrotic or anti-fibrotic, fibrotic expression of HSC Activation and Quiescence Markers are quantified after over-expressing the MiRNAs in LX2 cells. Our results suggest that MiRNA 150 is pro-fibrotic due to the relative over-expression of classical HSC activation markers while MiRNA 885 tends to be inconclusive with inconsistent results. This paper also serves as a guide for cloning and testing MiRNAs in cells for any gene expression in-vitro. MiRNA 150 can be further studied on a protein level for potential therapeutic value to those suffering from Liver fibrosis.
Schools: School of Chemical and Biomedical Engineering 
Organisations: A*STAR
Rights: Nanyang Technological University
Fulltext Permission: restricted
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Student Reports (FYP/IA/PA/PI)

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