Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/79313
Title: A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction
Authors: Martin, Fernando L.
Huang, Ying Ying
Venkatraman, Subbu Subramanian
Burnett, John C.
Chen, Horng H.
Lim, Soo Ghim
Jeson Sangaralingham, S.
Ameenuddin, Syed
Ng, Xu Wen
Issue Date: 2013
Source: Lim, S. G., Jeson Sangaralingham, S., Ameenuddin, S., Martin, F. L., Ng, X. W., Huang, Y. Y., et al. (2013). A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction. BMC Pharmacology and Toxicology, 14, 38-.
Series/Report no.: BMC pharmacology and toxicology
Abstract: CD-NP (Cenderitide) is the only chimeric natriuretic peptide that acts on both the A and B natriuretic peptide receptors (NPR). This differential mechanism of action reduces the arterial vasodilating properties, while retaining the cardiac unloading and aldosterone inhibiting actions of the NPR-A receptor in addition to the direct anti-remodeling actions of the NPR-B receptor. Our objective is to determine the effects of 3 weeks of sustained delivery of CD-NP via a single subcutaneous (SQ) injection of a fully biodegradable in-situ polymer precipitation delivery system (Gel system) in a model of experimental myocardial infarction (MI).
URI: https://hdl.handle.net/10356/79313
http://hdl.handle.net/10220/38543
ISSN: 2050-6511
DOI: 10.1186/2050-6511-14-S1-P38
Rights: © 2013 Lim et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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