Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/79313
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dc.contributor.authorMartin, Fernando L.en
dc.contributor.authorHuang, Ying Yingen
dc.contributor.authorVenkatraman, Subbu Subramanianen
dc.contributor.authorBurnett, John C.en
dc.contributor.authorChen, Horng H.en
dc.contributor.authorLim, Soo Ghimen
dc.contributor.authorJeson Sangaralingham, S.en
dc.contributor.authorAmeenuddin, Syeden
dc.contributor.authorNg, Xu Wenen
dc.date.accessioned2015-09-01T06:30:24Zen
dc.date.accessioned2019-12-06T13:22:19Z-
dc.date.available2015-09-01T06:30:24Zen
dc.date.available2019-12-06T13:22:19Z-
dc.date.copyright2013en
dc.date.issued2013en
dc.identifier.citationLim, S. G., Jeson Sangaralingham, S., Ameenuddin, S., Martin, F. L., Ng, X. W., Huang, Y. Y., et al. (2013). A biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarction. BMC Pharmacology and Toxicology, 14, 38-.en
dc.identifier.issn2050-6511en
dc.identifier.urihttps://hdl.handle.net/10356/79313-
dc.description.abstractCD-NP (Cenderitide) is the only chimeric natriuretic peptide that acts on both the A and B natriuretic peptide receptors (NPR). This differential mechanism of action reduces the arterial vasodilating properties, while retaining the cardiac unloading and aldosterone inhibiting actions of the NPR-A receptor in addition to the direct anti-remodeling actions of the NPR-B receptor. Our objective is to determine the effects of 3 weeks of sustained delivery of CD-NP via a single subcutaneous (SQ) injection of a fully biodegradable in-situ polymer precipitation delivery system (Gel system) in a model of experimental myocardial infarction (MI).en
dc.format.extent2 p.en
dc.language.isoenen
dc.relation.ispartofseriesBMC pharmacology and toxicologyen
dc.rights© 2013 Lim et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.titleA biodegradable in-situ polymer precipitation delivery system for sustained delivery of a novel chimeric natriuretic peptide CD-NP in an experimental model of myocardial infarctionen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science & Engineeringen
dc.identifier.doi10.1186/2050-6511-14-S1-P38en
dc.description.versionPublished versionen
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