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https://hdl.handle.net/10356/79354| Title: | Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs | Authors: | Koh, P.-F. Wang, P. Huang, J.-M. Loh, T.-P. |
Keywords: | DRNTU::Science::Chemistry | Issue Date: | 2014 | Source: | Koh, P.-F., Wang, P., Huang, J.-M., & Loh, T.-P. (2014). Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs. Chemical communications, 50(61), 8324-8327. | Series/Report no.: | Chemical communications | Abstract: | An efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps in 54% yield from biomass derived furfural. The synthetic utility of the piperidone core structure was demonstrated with the synthesis of a NK1 receptor antagonist. | URI: | https://hdl.handle.net/10356/79354 http://hdl.handle.net/10220/25021 |
ISSN: | 1359-7345 | DOI: | 10.1039/C4CC02645D | Rights: | © 2014 The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | SPMS Journal Articles |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Biomass derived furfural-based facile synthesis of protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs.pdf | 1.19 MB | Adobe PDF |  View/Open |
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