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Title: Novelty-induced phase-locked firing to slow gamma oscillations in the hippocampus : requirement of synaptic plasticity
Authors: Kitanishi, Takuma
Ujita, Sakiko
Fallahnezhad, Mehdi
Kitanishi, Naomi
Ikegaya, Yuji
Tashiro, Ayumu
Keywords: DRNTU::Science::Biological sciences::Human anatomy and physiology::Neurobiology
Issue Date: 2015
Source: Kitanishi, T., Ujita, S., Fallahnezhad, M., Kitanishi, N., Ikegaya, Y.,& Tashiro, A. (2015). Novelty-induced phase-locked firing to slow gamma oscillations in the hippocampus : requirement of synaptic plasticity. Neuron, 86(5), 1265-1276.
Series/Report no.: Neuron
Abstract: Temporally precise neuronal firing phase-locked to gamma oscillations is thought to mediate the dynamic interaction of neuronal populations, which is essential for information processing underlying higher-order functions such as learning and memory. However, the cellular mechanisms determining phase locking remain unclear. By devising a virus-mediated approach to perform multi-tetrode recording from genetically manipulated neurons, we demonstrated that synaptic plasticity dependent on the GluR1 subunit of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptor mediates two dynamic changes in neuronal firing in the hippocampal CA1 area during novel experiences: the establishment of phase-locked firing to slow gamma oscillations and the rapid formation of the spatial firing pattern of place cells. The results suggest a series of events potentially underlying the acquisition of new spatial information: slow gamma oscillations, originating from the CA3 area, induce the two GluR1-dependent changes of CA1 neuronal firing, which in turn determine information flow in the hippocampal-entorhinal system.
ISSN: 08966273
DOI: 10.1016/j.neuron.2015.05.012
Schools: School of Biological Sciences 
Rights: © 2015 [Elsevier] This is the author created version of a work that has been peer reviewed and accepted for publication by [Neuron], [Elsevier]. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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