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Title: Structure of the human telomere in Na+ solution : an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity
Authors: Lim, Kah Wai
Ng, Veronica Chinn Min
Martin-Pintado, Nerea
Heddi, Brahim
Phan, Anh Tuan
Keywords: DRNTU::Science::Biological sciences::Human anatomy and physiology::Deoxyribonucleic acids
Issue Date: 2013
Source: Lim, K. W., Ng, V. C. M., Martin-Pintado, N., Heddi, B., & Phan, A. T. (2013). Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity. Nucleic Acids Research, 41(22), 10556-10562.
Series/Report no.: Nucleic acids research
Abstract: Single-stranded DNA overhangs at the ends of human telomeric repeats are capable of adopting four-stranded G-quadruplex structures, which could serve as potential anticancer targets. Out of the five reported intramolecular human telomeric G-quadruplex structures, four were formed in the presence of K+ ions and only one in the presence of Na+ ions, leading often to a perception that this structural polymorphism occurs exclusively in the presence of K+ but not Na+. Here we present the structure of a new antiparallel (2+2) G-quadruplex formed by a derivative of a 27-nt human telomeric sequence in Na+ solution, which comprises a novel core arrangement distinct from the known topologies. This structure complements the previously elucidated basket-type human telomeric G-quadruplex to serve as reference structures in Na+-containing environment. These structures, together with the coexistence of other conformations in Na+ solution as observed by nuclear magnetic resonance spectroscopy, establish the polymorphic nature of human telomeric repeats beyond the influence of K+ ions.
DOI: 10.1093/nar/gkt771
Schools: School of Biological Sciences 
School of Physical and Mathematical Sciences 
Rights: © 2013 The Author(s) (Oxford University Press) This paper was published in Nucleic Acids Research and is made available as an electronic reprint (preprint) with permission of The Author(s). The paper can be found at the following official DOI: [ ].  One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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