Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/79377
Title: Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats
Authors: Liu, Albert
Jain, Neeraj
Vyas, Ajai
Lim, Lee Wei
Keywords: DRNTU::Science::Biological sciences::Zoology::Anatomy
Issue Date: 2015
Source: Liu, A., Jain, N., Vyas, A., & Lim, L. W. (2015). Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats. eLife, 2015(4), e04803-.
Series/Report no.: eLife
Abstract: Memory dysfunction is a key symptom of age-related dementia. Although recent studies have suggested positive effects of electrical stimulation for memory enhancement, its potential targets remain largely unknown. In this study, we hypothesized that spatially targeted deep brain stimulation of ventromedial prefrontal cortex enhanced memory functions in a middle-aged rat model. Our results show that acute stimulation enhanced the short-, but not the long-term memory in the novel-object recognition task. Interestingly, after chronic high-frequency stimulation, both the short- and long-term memories were robustly improved in the novel-object recognition test and Morris water-maze spatial task compared to sham. Our results also demonstrated that chronic ventromedial prefrontal cortex high-frequency stimulation upregulated neurogenesis-associated genes along with enhanced hippocampal cell proliferation. Importantly, these memory behaviors were strongly correlated with the hippocampal neurogenesis. Overall, these findings suggest that chronic ventromedial prefrontal cortex high-frequency stimulation may serve as a novel effective therapeutic target for dementia-related disorders.
URI: https://hdl.handle.net/10356/79377
http://hdl.handle.net/10220/25314
ISSN: 2050-084X
DOI: 10.7554/eLife.04803
Schools: School of Biological Sciences 
Rights: © 2015 The Author(s). This is the author created version of a work that has been peer reviewed and accepted for publication in eLife, published by eLife Sciences Publications on behalf of The Author(s).  It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document.  The published version is available at: [http://dx.doi.org/10.7554/eLife.04803].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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