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Title: Looking deeper : multimodal and contrast-enhanced photoacoustic imaging offer a clearer view within tissues for more accurate diagnosis
Authors: Pramanik, Manojit
Kim, Chulhong
Keywords: DRNTU::Science::Medicine::Tissue engineering
Issue Date: 2015
Source: Pramanik, M., & Kim, C. (2015). Looking deeper : multimodal and contrast-enhanced photoacoustic imaging offer a clearer view within tissues for more accurate diagnosis. IEEE pulse, 6(3), 38-41.
Series/Report no.: IEEE pulse
Abstract: Optical imaging modalities such as fluorescence (FL) microscopy, multiphoton microscopy, and optical coherence tomography (OCT) have been well established for high optical contrast and high spatial resolution imaging of biological tissues. However, as they are dependent on ballistic photons, these methods fail to image beyond ~1 mm or so inside biological tissue. In contrast, diffuse optical imaging (DOI), which uses multiple scattered photons for imaging, can image much deeper (up to a several centimeters) into the tissue. Unfortunately, due to strong light scattering in tissues, it fails to maintain the high resolution at the deeper imaging depth. Photoacoustic imaging (PAI) bridges this gap of imaging deeper with high resolution and contrast by combining optical excitation with acoustic detection [1].
DOI: 10.1109/MPUL.2015.2409101
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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