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|Title:||Dose-response algorithms for water-borne Pseudomonas aeruginosa folliculitis||Authors:||Roser, D. J.
Van Den Akker, B.
Haas, C. N.
Ashbolt, N. J.
Rice, S. A.
|Issue Date:||2014||Source:||Roser, D. J., Van Den Akker, B., Boase, S., Haas, C. N., Ashbolt, N. J., & Rice, S. A. Dose–response algorithms for water-borne Pseudomonas aeruginosa folliculitis. Epidemiology and infection,143(7), 1525-1537.||Series/Report no.:||Epidemiology and infection||Abstract:||We developed two dose–response algorithms for P. aeruginosa pool folliculitis using bacterial and lesion density estimates, associated with undetectable, significant, and almost certain folliculitis. Literature data were fitted to Furumoto & Mickey's equations, developed for plant epidermis-invading pathogens: N l = A ln(1 + BC) (log-linear model); Pinf = 1−e(−r c C) (exponential model), where A and B are 2.51644 × 107 lesions/m2 and 2.28011 × 10−11 c.f.u./ml P. aeruginosa, respectively; C = pathogen density (c.f.u./ml), N l = folliculitis lesions/m2, Pinf = probability of infection, and r C = 4·3 × 10−7 c.f.u./ml P. aeruginosa. Outbreak data indicates these algorithms apply to exposure durations of 41 ± 25 min. Typical water quality benchmarks (≈10−2 c.f.u./ml) appear conservative but still useful as the literature indicated repeated detection likely implies unstable control barriers and bacterial bloom potential. In future, culture-based outbreak testing should be supplemented with quantitative polymerase chain reaction and organic carbon assays, and quantification of folliculitis aetiology to better understand P. aeruginosa risks.||URI:||https://hdl.handle.net/10356/79420
|DOI:||10.1017/S0950268814002532||Schools:||School of Biological Sciences||Rights:||© 2014 Cambridge University Press. This paper was published in Epidemiology and Infection and is made available as an electronic reprint (preprint) with permission of Cambridge University Press. The paper can be found at the following official DOI: [http://dx.doi.org/10.1017/S0950268814002532]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SBS Journal Articles|
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