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Title: Super-resolution photoacoustic microscopy using photonic nanojets : a simulation study
Authors: Wen, Zhuo-Bin
Wu, Zhe
Pramanik, Manojit
Upputuri, Paul Kumar
Keywords: Photoacoustic microscopy
Issue Date: 2014
Source: Upputuri, P. K., Wen, Z.-B., Wu, Z., & Pramanik, M. (2014). Super-resolution photoacoustic microscopy using photonic nanojets : a simulation study. Journal of biomedical optics, 19(11),116003-.
Series/Report no.: Journal of biomedical optics
Abstract: Optical resolution photoacoustic microscopy (ORPAM) is important for various biomedical applications, such as the study of cellular structures, microcirculation systems, and tumor angiogenesis. However, the lateral resolution of a conventional ORPAM is limited by optical diffraction. In this work, we report a simulation study to achieve subdiffraction-limited super-resolution in ORPAM using microspheres. Laser radiation is focused through a microsphere to generate a photonic nanojet, which provides the possibility to break the diffraction limit in ORPAM by reducing the size of the excitation volume. In our simulations using microspheres, we observed improvement in the lateral resolution up to ∼fourfold compared to conventional ORPAM. The method is simple, cost effective, and can provide far-field resolution. This approach may provide new opportunities for many biomedical imaging applications that require finer resolution.
DOI: 10.1117/1.JBO.19.11.116003
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2014 Society of Photo-optical Instrumentation Engineers (SPIE). This paper was published in Journal of Biomedical Optics and is made available as an electronic reprint (preprint) with permission of Society of Photo-optical Instrumentation Engineers (SPIE). The paper can be found at the following official DOI: []. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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