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https://hdl.handle.net/10356/79539
Title: | Poly-ε-caprolactone/gelatin hybrid electrospun composite nanofibrous mats containing ultrasound assisted herbal extract : antimicrobial and cell proliferation study | Authors: | Ramalingam, Raghavendra Dhand, Chetna Ezhilarasu, Hariharan Prasannan, Praseetha Subramanian, Sundarapandian Leung, Chak Ming Ong, Seow Theng Mohammed Kamruddin Lakshminarayanan, Rajamani Ramakrishna, Seeram Verma, Navin Kumar Arunachalam, Kantha Deivi |
Keywords: | DRNTU::Science::Medicine Electrospun Hybrid Mats Ultrasound Assisted Extraction |
Issue Date: | 2019 | Source: | Ramalingam, R., Dhand, C., Leung, C. M., Ezhilarasu, H., Prasannan, P., Ong, S. T., . . . Arunachalam, K. D. (2019). Poly-ε-caprolactone/gelatin hybrid electrospun composite nanofibrous mats containing ultrasound assisted herbal extract : antimicrobial and cell proliferation study. Nanomaterials, 9(3), 462-. doi:10.3390/nano9030462 | Series/Report no.: | Nanomaterials | Abstract: | Electrospun fibers have emerged as promising materials in the field of biomedicine, due to their superior physical and cell supportive properties. In particular, electrospun mats are being developed for advanced wound dressing applications. Such applications require the firers to possess excellent antimicrobial properties in order to inhibit potential microbial colonization from resident and non-resident bacteria. In this study, we have developed Poly-ε-Caprolactone /gelatin hybrid composite mats loaded with natural herbal extract (Gymnema sylvestre) to prevent bacterial colonization. As-spun scaffolds exhibited good wettability and desirable mechanical properties retaining their fibrous structure after immersing them in phosphate buffered saline (pH 7.2) for up to 30 days. The initial burst release of Gymnema sylvestre prevented the colonization of bacteria as confirmed by the radial disc diffusion assay. Furthermore, the electrospun mats promoted cellular attachment, spreading and proliferation of human primary dermal fibroblasts and cultured keratinocytes, which are crucial parenchymal cell-types involved in the skin recovery process. Overall these results demonstrated the utility of Gymnema sylvestre impregnated electrospun PCL/Gelatin nanofibrous mats as an effective antimicrobial wound dressing. | URI: | https://hdl.handle.net/10356/79539 http://hdl.handle.net/10220/49050 |
ISSN: | 2079-4991 | DOI: | 10.3390/nano9030462 | Rights: | © 2019 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | LKCMedicine Journal Articles |
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