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Title: Poly-ε-caprolactone/gelatin hybrid electrospun composite nanofibrous mats containing ultrasound assisted herbal extract : antimicrobial and cell proliferation study
Authors: Ramalingam, Raghavendra
Dhand, Chetna
Ezhilarasu, Hariharan
Prasannan, Praseetha
Subramanian, Sundarapandian
Leung, Chak Ming
Ong, Seow Theng
Mohammed Kamruddin
Lakshminarayanan, Rajamani
Ramakrishna, Seeram
Verma, Navin Kumar
Arunachalam, Kantha Deivi
Keywords: DRNTU::Science::Medicine
Electrospun Hybrid Mats
Ultrasound Assisted Extraction
Issue Date: 2019
Source: Ramalingam, R., Dhand, C., Leung, C. M., Ezhilarasu, H., Prasannan, P., Ong, S. T., . . . Arunachalam, K. D. (2019). Poly-ε-caprolactone/gelatin hybrid electrospun composite nanofibrous mats containing ultrasound assisted herbal extract : antimicrobial and cell proliferation study. Nanomaterials, 9(3), 462-. doi:10.3390/nano9030462
Series/Report no.: Nanomaterials
Abstract: Electrospun fibers have emerged as promising materials in the field of biomedicine, due to their superior physical and cell supportive properties. In particular, electrospun mats are being developed for advanced wound dressing applications. Such applications require the firers to possess excellent antimicrobial properties in order to inhibit potential microbial colonization from resident and non-resident bacteria. In this study, we have developed Poly-ε-Caprolactone /gelatin hybrid composite mats loaded with natural herbal extract (Gymnema sylvestre) to prevent bacterial colonization. As-spun scaffolds exhibited good wettability and desirable mechanical properties retaining their fibrous structure after immersing them in phosphate buffered saline (pH 7.2) for up to 30 days. The initial burst release of Gymnema sylvestre prevented the colonization of bacteria as confirmed by the radial disc diffusion assay. Furthermore, the electrospun mats promoted cellular attachment, spreading and proliferation of human primary dermal fibroblasts and cultured keratinocytes, which are crucial parenchymal cell-types involved in the skin recovery process. Overall these results demonstrated the utility of Gymnema sylvestre impregnated electrospun PCL/Gelatin nanofibrous mats as an effective antimicrobial wound dressing.
ISSN: 2079-4991
DOI: 10.3390/nano9030462
Rights: © 2019 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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