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Title: Effects of F’, F-ANA and LNA modification on the stability of DNA G-quadruplex
Authors: Li, Zhe
Issue Date: 2013
Source: Li, Z. (2013, March). Effects of F’, F-ANA and LNA Modification on the Stability of DNA G-quadruplex. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore.
Abstract: Quadruplex is formed by G-tetrads (Fig. a) stacking and it forms at Guanine-rich region. G-quadruplex is reported to have anti-cancer and anti-HIV effect [1]. T0 quadruplex (Fig. b) studied in this project is in (4+0) conformation and has very high symmetry [2]. F’, F-ANA and LNA (Fig. d-f) are modified sugars and they are highly stable in biological condition, easy to synthesize and soluble in water. Thanks to these beneficial properties, F’, F-ANA and LNA are promising candidates for DNA and RNA based drug design [3-5]. In this project, The effects of F’, F-ANA and LNA modifications on thermal stability of G-quadruplex were studied on the platform of T0 G-quadruplex and characterized by UV melting. [1st Award]
Schools: School of Physical and Mathematical Sciences 
Rights: © 2013 The Author(s).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:URECA Posters

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