Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/79630
Full metadata record
DC FieldValueLanguage
dc.contributor.authorFung, Wai-Toen
dc.contributor.authorBeyzavi, Alien
dc.contributor.authorAbgrall, Patricken
dc.contributor.authorNguyen, Nam-Trungen
dc.contributor.authorLi, Hoi-Yeungen
dc.date.accessioned2012-04-12T05:54:42Zen
dc.date.accessioned2019-12-06T13:29:43Z-
dc.date.available2012-04-12T05:54:42Zen
dc.date.available2019-12-06T13:29:43Z-
dc.date.copyright2009en
dc.date.issued2009en
dc.identifier.citationFung, W. T., Beyzavi, A., Abgrall, P., Nguyen, N. T., & Li, H..Y. (2009). Microfluidic platform for controlling the differentiation of embryoid body. Lab on a Chip, 9(17), 2591–2595.en
dc.identifier.urihttps://hdl.handle.net/10356/79630-
dc.description.abstractEmbryonic stem (ES) cells are pluripotent cells, which can differentiate into any cell type. This cell type has often been implicated as an eminent source of renewable cells for tissue regeneration and cellular replacement therapies. Studies on manipulation of the various differentiation pathways have been at the forefront of research. There are many ways in which ES cells can be differentiated. One of the most common techniques is to initiate the development of embryoid bodies (EBs) by in vitro aggregation of ES cells. Thereafter, EBs can be induced to undergo differentiation into various cell lineages. In this article, we present a microfluidic platform using biocompatible materials, which is suitable for culturing EBs. The platform is based on a Y-channel device with two inlets for two different culturing media. An EB is located across both streams. Using the laminar characteristics at low Reynolds number and high Peclet numbers, we have induced cell differentiation on half of the EB while maintaining the other half in un-induced stages. The results prove the potential of using microfluidic technology for manipulation of EBs and ES cells in tissue engineering.en
dc.format.extent6 p.en
dc.language.isoenen
dc.relation.ispartofseriesLab on a chipen
dc.rights© 2009 Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by Lab on a Chip, Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: DOI: [http://dx.doi.org/10.1039/B903753E].en
dc.subjectDRNTU::Engineering::Mechanical engineeringen
dc.titleMicrofluidic platform for controlling the differentiation of embryoid bodiesen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen
dc.identifier.doi10.1039/B903753Een
dc.description.versionAccepted versionen
dc.identifier.rims145508en
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:MAE Journal Articles
Files in This Item:
File Description SizeFormat 
B903753E Fung 2009 revised.pdf340.48 kBAdobe PDFThumbnail
View/Open

SCOPUSTM   
Citations 5

76
Updated on Jun 15, 2024

Web of ScienceTM
Citations 5

69
Updated on Oct 26, 2023

Page view(s) 5

952
Updated on Jun 24, 2024

Download(s) 5

494
Updated on Jun 24, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.