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Title: Modeling of drug release from biodegradable triple-layered microparticles
Authors: Lee, Wei Li
Shi, Wenxiong
Low, Zheng Yang
Li, Shuzhou
Loo, Say Chye Joachim
Keywords: DRNTU::Engineering::Materials
Issue Date: 2012
Source: Lee, W. L., Shi, W., Low, Z. Y., Li, S., & Loo, S. C. J. (2012). Modeling of drug release from biodegradable triple-layered microparticles. Journal of biomedical materials research part A, 100A(12), 3353-3362.
Series/Report no.: Journal of biomedical materials research part A
Abstract: Numerous models that predict drug release from nonerodible reservoir-membrane sphere systems have been presented. Most of these models cater only to a phase of drug release from a constant reservoir. All these models, however, are not applicable to drug release from biodegradable triple-layered microparticle system, in which the drug-loaded core (reservoir) is surrounded by nondrug holding outer layers (membrane). In this article, a mathematical model was developed for ibuprofen release from degradable triple-layered microparticles made of poly(D,L-lactide-co-glycolide, 50:50) (PLGA), poly(L-lactide) (PLLA), and poly(ethylene-co-vinyl acetate, 40 wt % vinyl acetate) (EVA), where ibuprofen was localized within the nonconstant reservoir (EVA core). The model postulated that the drug release through the bulk-degrading PLLA and PLGA layers consisted of two mechanisms: simple diffusional release followed by a degradation-controlled release through a rate-limiting membrane. The proposed model showed very good match with the experimental data of release from microparticles of various layer thicknesses and particle sizes. The underlying drug release mechanisms are dictated by three parameters determined by the model, including constant characteristic of diffusion, end time point of simple diffusion-controlled release and partition coefficient of drug. The presented model is effective for understanding the drug release mechanisms and for the design of this type of dosage form.
ISSN: 1549-3296
DOI: 10.1002/jbm.a.34292
Schools: School of Materials Science & Engineering 
Rights: © 2012 Wiley Periodicals, Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of biomedical materials research part A, Wiley Periodicals, Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at:].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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