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Title: Self-Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging
Authors: Xie, Chen
Zhen, Xu
Lei, Qunli
Ni, Ran
Pu, Kanyi
Keywords: Photoacoustic imaging
Issue Date: 2017
Source: Xie, C., Zhen, X., Lei, Q., Ni, R., & Pu, K. (2017). Self-Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging. Advanced Functional Materials, 27(8), 1605397-.
Series/Report no.: Advanced Functional Materials
Abstract: Despite the advantages of semiconducting polymer nanoparticles (SPNs) over other inorganic nanoparticles for photoacoustic (PA) imaging, their synthetic method is generally limited to nanoprecipitation, which is likely to cause the issue of nanoparticle dissociation. The synthesis of near-infrared (NIR) absorbing semiconducting polymer amphiphiles (SPAs) that can spontaneously self-assemble into homogeneous nanoparticles for in vivo PA imaging is reported. As compared with their counterpart nanoparticles (SPN1) prepared through nanoprecipitation, SPAs generally have higher fluorescence quantum yields but similar size and PA brightness, making them superior over SPN1. Optical and simulation studies reveal that the poly(ethylene glycol) (PEG) grafting density plays a critical role in determining the packing of SP segments inside the core of nanoparticles, consequently affecting the optical properties. The small size and structurally stable nanostructure, in conjunction with a dense PEG shell, allow SPAs to passively target tumors of living mice after systemic administration, permitting both PA and fluorescence imaging of the tumors at signals that are ≈1.5-fold higher than that of liver. This study thus not only provides the first generation of amphiphilic optically active polymers for PA imaging, but also highlights the molecular guidelines for the development of organic NIR imaging nanomaterials.
ISSN: 1616-301X
Other Identifiers: 24 p.
DOI: 10.1002/adfm.201605397
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Advanced Functional Materials, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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