Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/80254
Title: Age specific differences in efficacy and safety for the CYD-tetravalent dengue vaccine
Authors: Wilder-Smith, Annelies
Massad, Eduardo
Keywords: Dengue
Vaccine
Efficacy
Age indication
Issue Date: 2016
Source: Wilder-Smith, A., & Massad, E. (2016). Age specific differences in efficacy and safety for the CYD-tetravalent dengue vaccine. Expert Review of Vaccines, 15(4), 437-441.
Series/Report no.: Expert Review of Vaccines
Abstract: CYD-TDV is the first dengue vaccine to have completed Phase 3 efficacy trials. Efficacy was consistently higher in those aged 9 and above for all variables studied: efficacy against virologically confirmed dengue of any severity and serotype, serotype specific efficacy, efficacy dependent on baseline seropositivity, efficacy against hospitalizations and efficacy against severe disease. Because of the higher efficacy and the absence of a safety signal, the age group with the best benefit of the use of CYD-TDV is individuals aged 9 and above - the age group for which licensure is now being sought.
URI: https://hdl.handle.net/10356/80254
http://hdl.handle.net/10220/40437
ISSN: 1476-0584
DOI: 10.1586/14760584.2016.1143366
Schools: Lee Kong Chian School of Medicine (LKCMedicine) 
Rights: © 2016 Taylor & Francis. This is the author created version of a work that has been peer reviewed and accepted for publication by Expert Review of Vaccines, Taylor & Francis. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1586/14760584.2016.1143366].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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