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|Title:||Dissecting Japan's Dengue Outbreak in 2014||Authors:||Wilder-Smith, A.
Quam, M. B.
Kamaraj, U. S.
|Keywords:||DRNTU::Science::Medicine||Issue Date:||2015||Source:||Quam, M. B., Sessions, O., Kamaraj, U. S., Rocklov, J.,& Wilder-Smith, A. (2016). Dissecting Japan's Dengue Outbreak in 2014. American Journal of Tropical Medicine and Hygiene, 94(2), 409-412.||Series/Report no.:||American Journal of Tropical Medicine and Hygiene||Abstract:||Despite Japan's temperate climate, a dengue outbreak occurred in Tokyo for the first time in over 70 years in 2014. We dissected this dengue outbreak based on phylogenetic analysis, travel interconnectivity, and environmental drivers for dengue epidemics. Comparing the available dengue virus 1 (DENV1) E gene sequence from this outbreak with 3,282 unique DENV1 sequences in National Center for Biotechnology Information suggested that the DENV might have been imported from China, Indonesia, Singapore, or Vietnam. With travelers arriving into Japan, Guangzhou (China) may have been the source of DENV introduction, given that Guangzhou also reported a large-scale dengue outbreak in 2014. Coinciding with the 2014 outbreak, Tokyo's climate conditions permitted the amplification of Aedes vectors and the annual peak of vectorial capacity. Given suitable vectors and climate conditions in addition to increasing interconnectivity with endemic areas of Asia, Tokyo's 2014 outbreak did not come as a surprise and may foretell more to come.||URI:||https://hdl.handle.net/10356/80256
|ISSN:||0002-9637||DOI:||10.4269/ajtmh.15-0468||Rights:||© 2016 The American Society of Tropical Medicine and Hygiene. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
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