Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/80263
Title: Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides
Authors: Lei, Chuanhu
Jin, Xiaojia
Zhou, Jianrong (Steve)
Keywords: cross-coupling
heterocycles
palladium
C-H activation
synthetic method
Issue Date: 2015
Source: Lei, C., Jin, X., & Zhou, J. (2015). Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides. Angewandte Chemie International Edition, 54(45), 13397-13400.
Series/Report no.: Angewandte Chemie International Edition
Abstract: Three-component couplings were achieved from common aryl halides, alkyl halides, and heteroarenes under palladium and norbornene co-catalysis. The reaction forges hindered aryl–heteroaryl bonds and introduces ortho-alkyl groups to aryl rings. Various heterocycles such as oxazoles, thiazoles and thiophenes underwent efficient coupling. The heteroarenes were deprotonated in situ by bases without the assistance of palladium catalysts.
URI: https://hdl.handle.net/10356/80263
http://hdl.handle.net/10220/40514
ISSN: 1433-7851
DOI: 10.1002/anie.201507128
Schools: School of Physical and Mathematical Sciences 
Rights: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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