Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/80269
Title: Palladium-Catalyzed Alkynylation and Concomitant ortho Alkylation of Aryl Iodides
Authors: Lei, Chuanhu
Jin, Xiaojia
Zhou, Jianrong (Steve)
Keywords: alkynylation
CH activation
Catellani reaction
benzofuran
palladium catalysis
Issue Date: 2016
Source: Lei, C., Jin, X., & Zhou, J. (2016). Palladium-Catalyzed Alkynylation and Concomitant ortho Alkylation of Aryl Iodides. ACS Catalysis, 6(3), 1635-1639.
Series/Report no.: ACS Catalysis
Abstract: We report an efficient alkynylation reaction of aryl iodides with simultaneous ortho-alkylaton of aryl rings. The reaction between three simple reagents—aryl halides, alkynes, and alkyl halides—formed aryl–alkynyl bonds carrying hindered aryl rings in one step. The reaction proceeded via a Catellani-type pathway in the presence of norbornene. From a synthetic perspective, this reaction allows quick access toward many 1,2,3-substituted arenes and multiply substituted benzofurans, after manipulation of alkyne groups. These compounds are difficult to synthesize otherwise.
URI: https://hdl.handle.net/10356/80269
http://hdl.handle.net/10220/40513
ISSN: 2155-5435
DOI: 10.1021/acscatal.6b00169
Schools: School of Physical and Mathematical Sciences 
Rights: © 2016 American Chemical Society.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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