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Title: Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons
Authors: Lyu, Yan
Xie, Chen
Chechetka, Svetlana A.
Miyako, Eijiro
Pu, Kanyi
Keywords: Semiconducting polymers
Activation of neurons
Issue Date: 2016
Source: Lyu, Y., Xie, C., Chechetka, S. A., Miyako, E., & Pu, K. (2016). Semiconducting Polymer Nanobioconjugates for Targeted Photothermal Activation of Neurons. Journal of the American Chemical Society, 138(29), 9049–9052.
Series/Report no.: Journal of the American Chemical Society
Abstract: Optogenetics provides powerful means for precise control of neuronal activity; however, the requirement of transgenesis and the incapability to extend the neuron excitation window into the deep-tissue-penetrating near-infrared (NIR) region partially limit its application. We herein report a potential alternative approach to optogenetics using semiconducting polymer nanobioconjugates (SPNsbc) as the photothermal nanomodulator to control the thermosensitive ion channels in neurons. SPNsbc are designed to efficiently absorb the NIR light at 808 nm and have a photothermal conversion efficiency higher than that of gold nanorods. By virtue of the fast heating capability in conjunction with the precise targeting to the thermosensitive ion channel, SPNsbc can specifically and rapidly activate the intracellular Ca2+ influx of neuronal cells in a reversible and safe manner. Our study provides an organic nanoparticle based strategy that eliminates the need for genetic transfection to remotely regulate cellular machinery.
ISSN: 0002-7863
DOI: 10.1021/jacs.6b05192
Schools: School of Chemical and Biomedical Engineering 
Rights: © 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Journal of the American Chemical Society, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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