Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/80297
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dc.contributor.authorGao, Xiaohongen
dc.contributor.authorGunalan, Karthigayanen
dc.contributor.authorYap, Sally Shu Linen
dc.contributor.authorPreiser, Peter R.en
dc.date.accessioned2015-11-19T08:47:59Zen
dc.date.accessioned2019-12-06T13:46:41Z-
dc.date.available2015-11-19T08:47:59Zen
dc.date.available2019-12-06T13:46:41Z-
dc.date.issued2013en
dc.identifier.citationGao, X., Gunalan, K., Yap, S. S. L., & Preiser, P. R. (2013). Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparum. Nature Communications, 4: 2862.en
dc.identifier.issn2041-1723en
dc.identifier.urihttps://hdl.handle.net/10356/80297-
dc.description.abstractInvasion of erythrocytes by Plasmodium falciparum merozoites is a complex multi-step process mediated by specific interactions between host receptors and parasite ligands. Reticulocytebinding protein homologues (RHs) and erythrocyte-binding-like (EBL) proteins are discharged from specialized organelles and used in early steps of invasion. Here we show that monoclonal antibodies against PfRH1 (an RH) block merozoite invasion by specifically inhibiting calcium signalling in the parasite, whereas invasion-inhibiting monoclonal antibodies targeting EBA175 (an EBL protein) have no effect on signalling. We further show that inhibition of this calcium signalling prevents EBA175 discharge and thereby formation of the junction between parasite and host cell. Our results indicate that PfRH1 has an initial sensing as well as signal transduction role that leads to the subsequent release of EBA175. They also provide new insights on how RH–host cell interactions lead to essential downstream signalling events in the parasite, suggesting new targets for malaria intervention.en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.format.extent11 p.en
dc.language.isoenen
dc.relation.ispartofseriesNature Communicationsen
dc.rights© 2013 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectCell biologyen
dc.subjectMicrobiologyen
dc.subjectBiological sciencesen
dc.titleTriggers of key calcium signals during erythrocyte invasion by Plasmodium falciparumen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.identifier.doi10.1038/ncomms3862en
dc.description.versionPublished versionen
dc.identifier.pmid24280897-
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