Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGao, Xiaohongen
dc.contributor.authorGunalan, Karthigayanen
dc.contributor.authorYap, Sally Shu Linen
dc.contributor.authorPreiser, Peter R.en
dc.identifier.citationGao, X., Gunalan, K., Yap, S. S. L., & Preiser, P. R. (2013). Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparum. Nature Communications, 4: 2862.en
dc.description.abstractInvasion of erythrocytes by Plasmodium falciparum merozoites is a complex multi-step process mediated by specific interactions between host receptors and parasite ligands. Reticulocytebinding protein homologues (RHs) and erythrocyte-binding-like (EBL) proteins are discharged from specialized organelles and used in early steps of invasion. Here we show that monoclonal antibodies against PfRH1 (an RH) block merozoite invasion by specifically inhibiting calcium signalling in the parasite, whereas invasion-inhibiting monoclonal antibodies targeting EBA175 (an EBL protein) have no effect on signalling. We further show that inhibition of this calcium signalling prevents EBA175 discharge and thereby formation of the junction between parasite and host cell. Our results indicate that PfRH1 has an initial sensing as well as signal transduction role that leads to the subsequent release of EBA175. They also provide new insights on how RH–host cell interactions lead to essential downstream signalling events in the parasite, suggesting new targets for malaria intervention.en
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en
dc.format.extent11 p.en
dc.relation.ispartofseriesNature Communicationsen
dc.rights© 2013 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit
dc.subjectCell biologyen
dc.subjectBiological sciencesen
dc.titleTriggers of key calcium signals during erythrocyte invasion by Plasmodium falciparumen
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen
dc.description.versionPublished versionen
item.fulltextWith Fulltext-
Appears in Collections:SBS Journal Articles
Files in This Item:
File Description SizeFormat 
ncomms3862.pdf1.28 MBAdobe PDFThumbnail

Citations 10

Updated on Jul 15, 2024

Web of ScienceTM
Citations 5

Updated on Oct 26, 2023

Page view(s) 50

Updated on Jul 16, 2024

Download(s) 50

Updated on Jul 16, 2024

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.