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Title: Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparum
Authors: Gao, Xiaohong
Gunalan, Karthigayan
Yap, Sally Shu Lin
Preiser, Peter R.
Keywords: Cell biology
Biological sciences
Issue Date: 2013
Source: Gao, X., Gunalan, K., Yap, S. S. L., & Preiser, P. R. (2013). Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparum. Nature Communications, 4: 2862.
Series/Report no.: Nature Communications
Abstract: Invasion of erythrocytes by Plasmodium falciparum merozoites is a complex multi-step process mediated by specific interactions between host receptors and parasite ligands. Reticulocytebinding protein homologues (RHs) and erythrocyte-binding-like (EBL) proteins are discharged from specialized organelles and used in early steps of invasion. Here we show that monoclonal antibodies against PfRH1 (an RH) block merozoite invasion by specifically inhibiting calcium signalling in the parasite, whereas invasion-inhibiting monoclonal antibodies targeting EBA175 (an EBL protein) have no effect on signalling. We further show that inhibition of this calcium signalling prevents EBA175 discharge and thereby formation of the junction between parasite and host cell. Our results indicate that PfRH1 has an initial sensing as well as signal transduction role that leads to the subsequent release of EBA175. They also provide new insights on how RH–host cell interactions lead to essential downstream signalling events in the parasite, suggesting new targets for malaria intervention.
ISSN: 2041-1723
DOI: 10.1038/ncomms3862
Schools: School of Biological Sciences 
Rights: © 2013 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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