Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/80333
Title: Toxoplasma gondii infection and testosterone congruently increase tolerance of male rats for risk of reward forfeiture
Authors: Tan, Donna
Vyas, Ajai
Keywords: BART
Decision making
Impulsivity
Behavioral manipulation
Parasitism
Steroids
Issue Date: 2016
Source: Tan, D., & Vyas, A. (2016). Toxoplasma gondii infection and testosterone congruently increase tolerance of male rats for risk of reward forfeiture. Hormones and Behavior, 79, 37-44.
Series/Report no.: Hormones and Behavior
Abstract: Decision making under risk involves balancing the potential of gaining rewards with the possibility of loss and/or punishment. Tolerance to risk varies between individuals. Understanding the biological basis of risk tolerance is pertinent because excessive tolerance contributes to adverse health and safety outcomes. Yet, not much is known about biological factors mediating inter-individual variability in this regard. We investigate if latent Toxoplasma gondii infection can cause risk tolerance. Using a rodent model of the balloon analogous risk task, we show that latent T. gondii infection leads to a greater tolerance of reward forfeiture. Furthermore, effects of the infection on risk can be recapitulated with testosterone supplementation alone, demonstrating that greater testosterone synthesis by the host post-infection is sufficient to change risk tolerance. T. gondii is a frequent parasite of humans and animals. Thus, the infection status can potentially explain some of the inter-individual variability in the risky decision making.
URI: https://hdl.handle.net/10356/80333
http://hdl.handle.net/10220/40482
ISSN: 0018-506X
DOI: 10.1016/j.yhbeh.2016.01.003
Schools: School of Biological Sciences 
Rights: © 2016 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Hormones and Behavior, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.yhbeh.2016.01.003].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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