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Title: Characterization of the plasmodium interspersed repeats (PIR) proteins of plasmodium chabaudi indicates functional diversity
Authors: Yam, Xue Yan
Brugat, Thibaut
Siau, Anthony
Lawton, Jennifer
Wong, Daniel S.
Farah, Abdirahman
Twang, Jing Shun
Gao, Xiaohong
Langhorne, Jean
Preiser, Peter Rainer
Keywords: Parasitology
Plasmodium Chabaudi
DRNTU::Science::Biological sciences
Issue Date: 2016
Source: Yam, X. Y., Brugat, T., Siau, A., Lawton, J., Wong, D. S., Farah, A., . . . Preiser, P. R. (2016). Characterization of the plasmodium interspersed repeats (PIR) proteins of plasmodium chabaudi indicates functional diversity. Scientific Reports, 6, 23449-. doi:10.1038/srep23449
Series/Report no.: Scientific Reports
Abstract: Plasmodium multigene families play a central role in the pathogenesis of malaria. The Plasmodium interspersed repeat (pir) genes comprise the largest multigene family in many Plasmodium spp. However their function(s) remains unknown. Using the rodent model of malaria, Plasmodium chabaudi, we show that individual CIR proteins have differential localizations within infected red cell (iRBC), suggesting different functional roles in a blood-stage infection. Some CIRs appear to be located on the surface of iRBC and merozoites and are therefore well placed to interact with host molecules. In line with this hypothesis, we show for the first time that a subset of recombinant CIRs bind mouse RBCs suggesting a role for CIR in rosette formation and/or invasion. Together, our results unravel differences in subcellular localization and ability to bind mouse erythrocytes between the members of the cir family, which strongly suggest different functional roles in a blood-stage infection.
DOI: 10.1038/srep23449
Schools: School of Biological Sciences 
Rights: © 2016 The Authors (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
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